Re-activation of a dormant tumor suppressor gene maspin by designed transcription factors
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چکیده
منابع مشابه
Regulation of the Arf Tumor Suppressor by E2F Transcription Factors
Effective tumor suppression requires the appropriate function of two major signaling pathways, the pRB-E2F growth-control pathway and the p53 stress-response pathway. Members of the E2F family of transcription factors are key downstream targets of the retinoblastoma protein, pRB, and mediate the activation of genes required for cellular proliferation. The Arf tumor suppressor is a key regulator...
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HLJ1 is a novel tumor and invasion suppressor that inhibits tumorigenesis and cancer metastasis. However, the mechanism of HLJ1 activation is currently unclear. Here, we identify an enhancer segment in the HLJ1 gene at -2,125 to -1,039 bp upstream of the transcription start site. A 50-bp element between -1,492 and -1,443 bp is the minimal enhancer segment, which includes the activator protein 1...
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C13ORF18 is frequently hypermethylated in cervical cancer but not in normal cervix and might serve as a biomarker for the early detection of cervical cancer in scrapings. As hypermethylation is often observed for silenced tumor suppressor genes (TSGs), hypermethylated biomarker genes might exhibit tumor suppressive activities upon re-expression. Epigenetic drugs are successfully exploited to re...
متن کاملDormant tumor-suppressor pathways in tumors.
It was initially thought that activation of a single oncogene such as Ras would result in tumorigenesis; however, this conclusion was based on studies in which immortalized cells were used as the target cells in transformation assays (1). Thus it was significant when in 1983 Newbold and Overell reported that an activated Ras gene failed to transform normal fibroblasts unless the fibroblasts wer...
متن کاملTissue-type plasminogen activator is a target of the tumor suppressor gene maspin.
The maspin protein has tumor suppressor activity in breast and prostate cancers. It inhibits cell motility and invasion in vitro and tumor growth and metastasis in nude mice. Maspin is structurally a member of the serpin (serine protease inhibitors) superfamily but deviates somewhat from classical serpins. We find that single-chain tissue plasminogen activator (sctPA) specifically interacts wit...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2006
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1210072